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Article

IL‐4 induces expression of TARC/CCL17 via two STAT6 binding sites

30 Jun 2006

Abstract excerpt

A cardinal feature of allergic disorders and immune responses is enhanced leukocyte trafficking. This is largely orchestrated by chemokines. The CC chemokine thymus- and activation-regulated chemokine (TARC/CCL17) selectively attracts Th2 cells via the G protein-coupled chemokine receptor CCR4. We show here that TARC/CCL17 is expressed by human T cells upon stimulation with IL-4. Mapping of the transcriptional...

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PMID: 16810739
DOI: 10.1002/eji.200635972

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