Article
Atopic dermatitis is associated with a functional mutation in the promoter of the C-C chemokine RANTES.
Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2000
Nickel R G, Casolaro V, Wahn U, Beyer K, Barnes K C, Plunkett B S, Freidhoff L R, Sengler C, Plitt J R, Schleimer R P, Caraballo L, Naidu R P, Levett P N, Beaty T H, Huang S K
Abstract excerpt
Up-regulation of C-C chemokine expression characterizes allergic inflammation and atopic diseases. A functional mutation in the proximal promoter of the RANTES gene has been identified, which results in a new consensus binding site for the GATA transcription factor family. A higher frequency of this allele was observed in individuals of African descent compared with Caucasian subjects (p < 0.00001). The mutant...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.