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Article

IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2010

Ho Allen W, Shen Fang, Conti Heather R, Patel Nayan, Childs Erin E, Peterson Alanna C, Hernández-Santos Nydiaris, Kolls Jay K, Kane Lawrence P, Ouyang Wenjun, Gaffen Sarah L

Abstract excerpt

IL-17 mediates essential inflammatory responses in host defense and autoimmunity. The IL-17A-IL-17F signaling complex is composed of IL-17RA and IL-17RC, both of which are necessary for signal transduction. To date, the specific contribution of IL-17RC to downstream signaling remains poorly understood. To define the regions within the IL-17RC cytoplasmic tail required for signal transduction, we assayed signaling...

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Identifiers

PMID: 20554964
DOI: 10.4049/jimmunol.0903739
PMCID: PMC2897912

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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