Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation.

The EMBO journal - 12 Jul 2006

McGowan Sheena, Buckle Ashley M, Irving James A, Ong Poh Chee, Bashtannyk-Puhalovich Tanya A, Kan Wan-Ting, Henderson Kate N, Bulynko Yaroslava A, Popova Evgenya Y, Smith A Ian, Bottomley Stephen P, Rossjohn Jamie, Grigoryev Sergei A, Pike Robert N, Whisstock James C

Abstract excerpt

Most serpins are associated with protease inhibition, and their ability to form loop-sheet polymers is linked to conformational disease and the human serpinopathies. Here we describe the structural and functional dissection of how a unique serpin, the non-histone architectural protein, MENT (Myeloid and Erythroid Nuclear Termination stage-specific protein), participates in DNA and chromatin condensation. Our data...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cathepsin L
Share to Cathepsins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatin

Share to Crystallography, X-Ray

Share to Cysteine Endopeptidases

Share to Nucleosomes

Share to Protein Conformation

Share to Serpins

Source

Open in PubMed Open full text

Identifiers

PMID: 16810322
DOI: 10.1038/sj.emboj.7601201
PMCID: PMC1500978

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation.PMID 16810322Read ↗

Structural basis of human TREX1 DNA degradation and autoimmune disease.Semantic proximity Read ↗

Mechanistic insights into chromatin modulation by the “orphan” remodeler ATRXSemantic proximity Read ↗

A Unified Model: Chromatin-Bound Multicomponent Condensates.Semantic proximity Read ↗

<i>In-cell</i> structure of a LINC complex reveals the molecular basis for membrane remodelling and head-to-tail coupling in sperm cellsSemantic proximity Read ↗

All in the family: evidence for four new LEM-domain proteins Lem2 (NET-25), Lem3, Lem4 and Lem5 in the human genome.Semantic proximity Read ↗

Structural Mechanisms of SAMD9 Autoinhibition and Pathogenic DysregulationSemantic proximity Read ↗

Treacle’s ability to form liquid-like phase condensates is essential for nucleolar fibrillar center assembly, efficient rRNA transcription and processing, and rRNA gene repairSemantic proximity Read ↗

Arginine-Enriched Mixed-Charge Domains Provide Cohesion for Nuclear Speckle Condensation.Semantic proximity Read ↗

Structural studies of the Msx-1 homeodomain-DNA complex I.Semantic proximity Read ↗

Cryo-EM structures of SAMD9L reveal the arrangement and coordination of multi-domainsSemantic proximity Read ↗

Hierarchical Anchoring–Gating Dictates Specific H4K16 Acetylation by the Human MSL ComplexSemantic proximity Read ↗

MORC2 Mediates Transcriptional Regulation Through Liquid-Liquid Phase SeparationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.