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Article

Stabilization of the retinoblastoma protein by A-type nuclear lamins is required for INK4A-mediated cell cycle arrest.

Molecular and cellular biology - 1 Jul 2006

Nitta Ryan T, Jameson Samantha A, Kudlow Brian A, Conlan Lindus A, Kennedy Brian K

Abstract excerpt

Mutations in the LMNA gene, which encodes all A-type lamins, including lamin A and lamin C, cause a variety of tissue-specific degenerative diseases termed laminopathies. Little is known about the pathogenesis of these disorders. Previous studies have indicated that A-type lamins interact with the retinoblastoma protein (pRB). Here we probe the functional consequences of this association and further examine links...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to G1 Phase

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Source

Open in PubMed Open full text

Identifiers

PMID: 16809772
DOI: 10.1128/MCB.02464-05
PMCID: PMC1592700

Genes

LMNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Stabilization of the retinoblastoma protein by A-type nuclear lamins is required for INK4A-mediated cell cycle arrest.PMID 16809772Read ↗

A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation.Semantic proximity Read ↗

Retinoblastoma-independent regulation of cell proliferation and senescence by the p53-p21 axis in lamin A /C-depleted cells.Semantic proximity Read ↗

Evidence that proteasome-dependent degradation of the retinoblastoma protein in cells lacking A-type lamins occurs independently of gankyrin and MDM2.Semantic proximity Read ↗

Prelamin A processing and heterochromatin dynamics in laminopathies.Semantic proximity Read ↗

The effect of the lamin A and its mutants on nuclear structure, cell proliferation, protein stability, and mobility in embryonic cells.Semantic proximity Read ↗

The farnesyl transferase inhibitor (FTI) lonafarnib improves nuclear morphology in ZMPSTE24-deficient fibroblasts from patients with the progeroid disorder MAD-B.Semantic proximity Read ↗

Involvement of prelamin A in laminopathies.Semantic proximity Read ↗

The R527H mutation in LMNA gene causes an increased sensitivity to ionizing radiation.Semantic proximity Read ↗

Direct synthesis of lamin A, bypassing prelamin a processing, causes misshapen nuclei in fibroblasts but no detectable pathology in mice.Semantic proximity Read ↗

Lamin B1 fluctuations have differential effects on cellular proliferation and senescence.Semantic proximity Read ↗

Pre-Lamin A processing is linked to heterochromatin organization.Semantic proximity Read ↗

Prelamin A processing, accumulation and distribution in normal cells and laminopathy disorders.Semantic proximity Read ↗

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