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Article

The R527H mutation in LMNA gene causes an increased sensitivity to ionizing radiation.

Cell cycle (Georgetown, Tex.) - 1 Jul 2008

di Masi Alessandra, D'Apice Maria Rosaria, Ricordy Ruggero, Tanzarella Caterina, Novelli Giuseppe

Abstract excerpt

Mandibuloacral dysplasia type A (MADA; OMIM # 248370) is a premature ageing disease caused by the homozygous R527H mutation in the LMNA gene. At the cellular level, MADA is characterized by unprocessed prelamin A accumulation, nuclear architecture alterations, chromatin defects and increased inci...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18604166
DOI: 10.4161/cc.7.13.6149

Genes

LMNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18604166-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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