Article
Lamin B1 fluctuations have differential effects on cellular proliferation and senescence.
The Journal of cell biology - 4 Mar 2013
Dreesen Oliver, Chojnowski Alexandre, Ong Peh Fern, Zhao Tian Yun, Common John E, Lunny Declan, Lane E Birgitte, Lee Shu Jin, Vardy Leah A, Stewart Colin L, Colman Alan
Abstract excerpt
The nuclear lamina consists of A- and B-type lamins. Mutations in LMNA cause many human diseases, including progeria, a premature aging syndrome, whereas LMNB1 duplication causes adult-onset autosomal dominant leukodystrophy (ADLD). LMNB1 is reduced in cells from progeria patients, but the significance of this reduction is unclear. In this paper, we show that LMNB1 protein levels decline in senescent human dermal...
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