Article
The effect of the lamin A and its mutants on nuclear structure, cell proliferation, protein stability, and mobility in embryonic cells.
Chromosoma - 1 Aug 2017
Piekarowicz Katarzyna, Machowska Magdalena, Dratkiewicz Ewelina, Lorek Daria, Madej-Pilarczyk Agnieszka, Rzepecki Ryszard
Abstract excerpt
LMNA gene encodes for nuclear intermediate filament proteins lamin A/C. Mutations in this gene lead to a spectrum of genetic disorders, collectively referred to as laminopathies. Lamin A/C are widely expressed in most differentiated somatic cells but not in early embryos and some undifferentiated cells. To investigate the role of lamin A/C in cell phenotype maintenance and differentiation, which could be a...
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