Article
A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation.
Proceedings of the National Academy of Sciences of the United States of America - 29 Jun 2004
Johnson Brett R, Nitta Ryan T, Frock Richard L, Mounkes Leslie, Barbie David A, Stewart Colin L, Harlow Ed, Kennedy Brian K
Abstract excerpt
The retinoblastoma protein (pRB) is a critical regulator of cell proliferation and differentiation and an important tumor suppressor. In the G(1) phase of the cell cycle, pRB localizes to perinucleolar sites associated with lamin A/C intranuclear foci. Here, we examine pRB function in cells lacking lamin A/C, finding that pRB levels are dramatically decreased and that the remaining pRB is mislocalized. We...
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