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Article

Evidence that proteasome-dependent degradation of the retinoblastoma protein in cells lacking A-type lamins occurs independently of gankyrin and MDM2.

PloS one - 26 Sept 2007

Nitta Ryan T, Smith Catherine L, Kennedy Brian K

Abstract excerpt

BACKGROUND: A-type lamins, predominantly lamins A and C, are nuclear intermediate filaments believed to act as scaffolds for assembly of transcription factors. Lamin A/C is necessary for the retinoblastoma protein (pRB) stabilization through unknown mechanism(s). Two oncoproteins, gankyrin and MDM2, are known to promote pRB degradation in other contexts. Consequently, we tested the hypothesis that gankyrin and/or...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17896003
DOI: 10.1371/journal.pone.0000963
PMCID: PMC1978514

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Evidence that proteasome-dependent degradation of the retinoblastoma protein in cells lacking A-type lamins occurs independently of gankyrin and MDM2.PMID 17896003Read ↗

Stabilization of the retinoblastoma protein by A-type nuclear lamins is required for INK4A-mediated cell cycle arrest.Semantic proximity Read ↗

A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation.Semantic proximity Read ↗

Regulation of p14ARF expression by miR-24: a potential mechanism compromising the p53 response during retinoblastoma developmentSemantic proximity Read ↗

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Nuclear accumulation of UBC9 contributes to SUMOylation of lamin A/C and nucleophagy in response to DNA damageSemantic proximity Read ↗

Structure of the oncoprotein gankyrin in complex with S6 ATPase of the 26S proteasome.Semantic proximity Read ↗

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