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Article

Evidence that proteasome-dependent degradation of the retinoblastoma protein in cells lacking A-type lamins occurs independently of gankyrin and MDM2.

PloS one - 26 Sept 2007

Nitta Ryan T, Smith Catherine L, Kennedy Brian K

Abstract excerpt

BACKGROUND: A-type lamins, predominantly lamins A and C, are nuclear intermediate filaments believed to act as scaffolds for assembly of transcription factors. Lamin A/C is necessary for the retinoblastoma protein (pRB) stabilization through unknown mechanism(s). Two oncoproteins, gankyrin and MD...

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Share to Cyclin-Dependent Kinase Inhibitor p16
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-mdm2

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Source

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Identifiers

PMID: 17896003
DOI: 10.1371/journal.pone.0000963
PMCID: PMC1978514

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17896003-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

Evidence that proteasome-dependent degradation of the retinoblastoma protein in cells lacking A-type lamins occurs independently of gankyrin and MDM2.PMID 17896003Read ↗

Stabilization of the retinoblastoma protein by A-type nuclear lamins is required for INK4A-mediated cell cycle arrest.Semantic proximity Read ↗

A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation.Semantic proximity Read ↗

Regulation of p14ARF expression by miR-24: a potential mechanism compromising the p53 response during retinoblastoma developmentSemantic proximity Read ↗

Retinoblastoma-independent regulation of cell proliferation and senescence by the p53-p21 axis in lamin A /C-depleted cells.Semantic proximity Read ↗

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.Semantic proximity Read ↗

Nuclear accumulation of UBC9 contributes to SUMOylation of lamin A/C and nucleophagy in response to DNA damageSemantic proximity Read ↗

Proteasome-mediated degradation of integral inner nuclear membrane protein emerin in fibroblasts lacking A-type lamins.Semantic proximity Read ↗

Intact MDM2 E3 ligase activity is required for the cytosolic localization and function of β-arrestin2.Semantic proximity Read ↗

The R527H mutation in LMNA gene causes an increased sensitivity to ionizing radiation.Semantic proximity Read ↗

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