Article
Direct synthesis of lamin A, bypassing prelamin a processing, causes misshapen nuclei in fibroblasts but no detectable pathology in mice.
The Journal of biological chemistry - 2 Jul 2010
Coffinier Catherine, Jung Hea-Jin, Li Ziwei, Nobumori Chika, Yun Ui Jeong, Farber Emily A, Davies Brandon S, Weinstein Michael M, Yang Shao H, Lammerding Jan, Farahani Javad N, Bentolila Laurent A, Fong Loren G, Young Stephen G
Abstract excerpt
Lamin A, a key component of the nuclear lamina, is generated from prelamin A by four post-translational processing steps: farnesylation, endoproteolytic release of the last three amino acids of the protein, methylation of the C-terminal farnesylcysteine, and finally, endoproteolytic release of the last 15 amino acids of the protein (including the farnesylcysteine methyl ester). The last cleavage step, mediated by...
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