Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pre-Lamin A processing is linked to heterochromatin organization.

Journal of cellular biochemistry - 1 Dec 2007

Lattanzi Giovanna, Columbaro Marta, Mattioli Elisabetta, Cenni Vittoria, Camozzi Daria, Wehnert Manfred, Santi Spartaco, Riccio Massimo, Del Coco Rosalba, Maraldi Nadir M, Squarzoni Stefano, Foisner Roland, Capanni Cristina

Abstract excerpt

Pre-lamin A undergoes subsequent steps of post-translational modification at its C-terminus, including farnesylation, methylation, and cleavage by ZMPSTE24 metalloprotease. Here, we show that accumulation of different intermediates of pre-lamin A processing in nuclei, induced by expression of mut...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biopsy, Needle
Share to Chromobox Protein Homolog 5

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomal Proteins, Non-Histone

Share to Fluorescent Antibody Technique, Indirect

Share to Heterochromatin

Share to Lamin Type A

Share to Precipitin Tests

Share to Protein Precursors

Source

Identifiers

PMID: 17654502
DOI: 10.1002/jcb.21467

Genes

ZMPSTE24

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17654502-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pre-Lamin A processing is linked to heterochromatin organization.PMID 17654502Read ↗

Prelamin A processing and heterochromatin dynamics in laminopathies.Semantic proximity Read ↗

Laminopathy-causing lamin A mutations reconfigure lamina-associated domains and local spatial chromatin conformation.Semantic proximity Read ↗

Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin.Semantic proximity Read ↗

Prelamin A processing, accumulation and distribution in normal cells and laminopathy disorders.Semantic proximity Read ↗

Lamin A/C maintains genome topology and regulates transcriptional programs essential for virus-driven B cell activationSemantic proximity Read ↗

Nuclear lamins: key regulators of nuclear structure and activities.Semantic proximity Read ↗

The effect of the lamin A and its mutants on nuclear structure, cell proliferation, protein stability, and mobility in embryonic cells.Semantic proximity Read ↗

Diverse lamin-dependent mechanisms interact to control chromatin dynamics. Focus on laminopathies.Semantic proximity Read ↗

Direct synthesis of lamin A, bypassing prelamin a processing, causes misshapen nuclei in fibroblasts but no detectable pathology in mice.Semantic proximity Read ↗

Mechanistic and Epigenetic Partitioning of Lamina-Associated Chromatin Revealed by a Genome-Wide Imaging ScreenSemantic proximity Read ↗

Lamin A/C as a Molecular Link Between Nuclear Organization, Chromatin Dynamics, and Tumor ProgressionSemantic proximity Read ↗

Depolymerized lamins link nuclear envelope breakdown to mitotic transcriptional quiescenceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.