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Article

Intron removal requires proofreading of U2AF/3' splice site recognition by DEK.

Science (New York, N.Y.) - 30 Jun 2006

Soares Luis Miguel Mendes, Zanier Katia, Mackereth Cameron, Sattler Michael, Valcárcel Juan

Abstract excerpt

Discrimination between splice sites and similar, nonsplice sequences is essential for correct intron removal and messenger RNA formation in eukaryotes. The 65- and 35-kD subunits of the splicing factor U2AF, U2AF65 and U2AF35, recognize, respectively, the pyrimidine-rich tract and the conserved terminal AG present at metazoan 3' splice sites. We report that DEK, a chromatin- and RNA-associated protein mutated or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16809543
DOI: 10.1126/science.1128659

Genes

DEK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Intron removal requires proofreading of U2AF/3' splice site recognition by DEK.PMID 16809543Read ↗

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Novel examples of NMD escape through alternative intronic polyadenylationSemantic proximity Read ↗

Pre-mRNA Splicing Factor U2AF2 Recognizes Distinct Conformations of Nucleotide Variants at the Center of the pre-mRNA Splice Site SignalSemantic proximity Read ↗

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Structure-guided U2AF65 variant improves recognition and splicing of a defective pre-mRNA.Semantic proximity Read ↗

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