Article
Retracing the evolution of amino acid specificity in glutaminyl-tRNA synthetase.
FEBS letters - 28 Aug 1998
Hong K W, Ibba M, Söll D
Abstract excerpt
Molecular phylogenetic studies of glutaminyl-tRNA synthetase suggest that it has relatively recently evolved from the closely related enzyme glutamyl-tRNA synthetase. We have now attempted to retrace one of the key steps in this process by selecting glutaminyl-tRNA synthetase mutants displaying e...
Topics
- Amino Acid Sequence
- Amino Acyl-tRNA Synthetases
- Animals
- Binding Sites
- Evolution, Molecular
- Glutamic Acid
- Humans
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Sequence Alignment