Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Retracing the evolution of amino acid specificity in glutaminyl-tRNA synthetase.

FEBS letters - 28 Aug 1998

Hong K W, Ibba M, Söll D

Abstract excerpt

Molecular phylogenetic studies of glutaminyl-tRNA synthetase suggest that it has relatively recently evolved from the closely related enzyme glutamyl-tRNA synthetase. We have now attempted to retrace one of the key steps in this process by selecting glutaminyl-tRNA synthetase mutants displaying enhanced glutamic acid recognition. Mutagenesis of two residues proximal to the active site, Phe-90 and Tyr-240, was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Binding Sites
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glutamic Acid

Share to Molecular Sequence Data

Share to Mutagenesis, Site-Directed

Share to Mutation

Share to Sequence Alignment

Source

Identifiers

PMID: 9738468
DOI: 10.1016/s0014-5793(98)00968-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Retracing the evolution of amino acid specificity in glutaminyl-tRNA synthetase.PMID 9738468Read ↗

Glutaminyl-tRNA synthetase: from genetics to molecular recognition.Semantic proximity Read ↗

A chimaeric glutamyl:glutaminyl-tRNA synthetase: implications for evolution.Semantic proximity Read ↗

Divergent anticodon recognition in contrasting glutamyl-tRNA synthetases.Semantic proximity Read ↗

Glutaminyl-tRNA synthetase.Semantic proximity Read ↗

tRNA(2Gln) mutants that translate the CGA arginine codon as glutamine in Escherichia coli.Semantic proximity Read ↗

tRNA recognition by glutamyl-tRNA reductase.Semantic proximity Read ↗

Aptamer redesigned tRNA is nonfunctional and degraded in cells.Semantic proximity Read ↗

Selectivity and specificity in the recognition of tRNA by E coli glutaminyl-tRNA synthetase.Semantic proximity Read ↗

Progress toward the evolution of an organism with an expanded genetic code.Semantic proximity Read ↗

A glycine hinge for tRNA-dependent translocation of editing substrates to prevent errors by leucyl-tRNA synthetase.Semantic proximity Read ↗

Preliminary X-ray crystallographic analysis of an engineered glutamyl-tRNA synthetase from Escherichia coli.Semantic proximity Read ↗

Influence of transfer RNA tertiary structure on aminoacylation efficiency by glutaminyl and cysteinyl-tRNA synthetases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.