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Article

BRCA1 suppresses osteopontin-mediated breast cancer.

The Journal of biological chemistry - 8 Sept 2006

El-Tanani Mohamed K, Campbell Frederick Charles, Crowe Paul, Erwin Pauline, Harkin Denis Paul, Pharoah Paul, Ponder Bruce, Rudland Philip S

Abstract excerpt

BRCA1 is a well described breast cancer susceptibility gene thought to be involved primarily in DNA repair. However, mutation within the BRCA1 transcriptional domain is also implicated in neoplastic transformation of mammary epithelium, but responsible mechanisms are unclear. Here we show in a ra...

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Share to BRCA1 Protein
Share to Breast Neoplasms
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Estrogen Receptor alpha

Share to Mammary Neoplasms, Experimental

Share to Osteopontin

Share to RNA, Small Interfering

Source

Identifiers

PMID: 16807234
DOI: 10.1074/jbc.M604403200

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16807234-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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BRCA1 suppresses osteopontin-mediated breast cancer.PMID 16807234Read ↗

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Mechanisms of BRCA1 tumor suppression.Semantic proximity Read ↗

Differential osteopontin expression in phenotypically distinct subclones of murine breast cancer cells mediates metastatic behavior.Semantic proximity Read ↗

Wild-type BRCA1, but not mutated BRCA1, regulates the expression of the nuclear form of beta-catenin.Semantic proximity Read ↗

An osteopontin splice variant induces anchorage independence in human breast cancer cells.Semantic proximity Read ↗

Role of the tumor suppressor gene Brca1 in genetic stability and mammary gland tumor formation.Semantic proximity Read ↗

Role of direct interaction in BRCA1 inhibition of estrogen receptor activity.Semantic proximity Read ↗

A role of estrogen/ERalpha signaling in BRCA1-associated tissue-specific tumor formation.Semantic proximity Read ↗

Role of osteopontin in tumour progressionSemantic proximity Read ↗

Mutant BRCA1 genes antagonize phenotype of wild-type BRCA1.Semantic proximity Read ↗

Direct interaction between BRCA1 and the estrogen receptor regulates vascular endothelial growth factor (VEGF) transcription and secretion in breast cancer cells.Semantic proximity Read ↗

Osteopontin up-regulates critical epithelial-mesenchymal transition transcription factors to induce an aggressive breast cancer phenotype.Semantic proximity Read ↗

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