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Article

Osteopontin up-regulates critical epithelial-mesenchymal transition transcription factors to induce an aggressive breast cancer phenotype.

Journal of the American College of Surgeons - 1 Jul 2013

Li Neill Y, Weber Cynthia E, Mi Zhiyong, Wai Philip Y, Cuevas Bruce D, Kuo Paul C

Abstract excerpt

BACKGROUND: Tumor cells undergoing epithelial-mesenchymal transition (EMT) develop cellular properties leading to stroma invasion and intravasation. We have previously shown in a xenograft breast cancer model that blocking osteopontin (OPN), a secreted phosphoprotein, decreases EMT. This study examines OPN's role in EMT initiation through its regulation of EMT transcription factors (TFs) Snail, Slug, and Twist....

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Source

Identifiers

PMID: 23619316
DOI: 10.1016/j.jamcollsurg.2013.02.025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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