Article
Genetic polymorphisms and haplotype structures of the CYP4A22 gene in a Japanese population.
Mutation research - 25 Jul 2006
Hiratsuka Masahiro, Nozawa Hisayoshi, Katsumoto Yuya, Moteki Toshiko, Sasaki Takamitsu, Konno Yumiko, Mizugaki Michinao
Abstract excerpt
The CYP4A fatty acid monooxygenases oxidize endogenous arachidonic acid to 20-hydroxyeicosatetraenoic acid that acts as a regulator of blood pressure. Among the isoforms of the CYP4A subfamily, the human CYP4A22 was recently identified. In this study, we report the comprehensive investigation of polymorphisms in the CYP4A22 gene. To investigate genetic variation in CYP4A22 in 191 Japanese subjects, we used...
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