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Article

Noncatalytic function of ERK1/2 can promote Raf/MEK/ERK-mediated growth arrest signaling.

The Journal of biological chemistry - 27 Nov 2009

Hong Seung-Keun, Yoon Seunghee, Moelling Cas, Arthan Dumrongkiet, Park Jong-In

Abstract excerpt

Kinase activity is known as the key biochemical property of MAPKs. Here, we report that ERK1/2 also utilizes its noncatalytic function to mediate certain signal transductions. Sustained activation of the Raf/MEK/ERK pathway induces growth arrest, accompanied by changes in cell cycle regulators (d...

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Source

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Identifiers

PMID: 19805545
DOI: 10.1074/jbc.M109.012591
PMCID: PMC2785141

Genes

ELK1
RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19805545-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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