Article
Contribution of KIR3DL1/3DS1 to ankylosing spondylitis in human leukocyte antigen-B27 Caucasian populations.
Arthritis research & therapy - 1 Jan 2006
Lopez-Larrea Carlos, Blanco-Gelaz Miguel Angel, Torre-Alonso Juan Carlos, Bruges Armas Jacome, Suarez-Alvarez Beatriz, Pruneda Laura, Couto Ana Rita, Gonzalez Segundo, Lopez-Vázquez Antonio, Martinez-Borra Jesus
Abstract excerpt
Killer cell immunoglobulin-like receptors (KIRs) and human leukocyte antigen (HLA) loci are both highly polymorphic, and some HLA class I molecules bind and trigger cell-surface receptors specified by KIR genes. We examined whether the combination of KIR3DS1/3DL1 genes in concert with HLA-B27 genotypes is associated with susceptibility to ankylosing spondylitis (AS). Two HLA-B27-positive Caucasian populations...
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