Article
Study on the protective effect of the KIR3DL1 gene in ankylosing spondylitis.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Nov 2015
Vendelbosch S, Heslinga S C, John M, van Leeuwen K, Geissler J, de Boer M, Tanck M W T, van den Berg T K, Crusius J B A, van der Horst-Bruinsma I E, Kuijpers T W
Abstract excerpt
OBJECTIVE: Ankylosing spondylitis (AS) is an autoimmune disease that mainly affects the sacroiliac joints and the spine of the lower back. The disease is strongly associated with HLA-B27. Additional genes, single-nucleotide polymorphisms, and molecular components have been identified to be associated with AS, but the exact mechanism that drives disease development remains poorly understood. The killer cell...
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