Article
Association of type 1 diabetes mellitus with the HLA-DQA1*0301 allele in a Tunisian population.
Research in immunology - 1 Jan 2000
Bardi R, Ju L Y, Jenhani S, Ayed K, Chammakhi S, Charron D
Abstract excerpt
HLA class II antigens are transmembrane glycosylated heterodimers composed of an alpha and a beta chain. Several of these chains are highly polymorphic. The structural bases of the polymorphism are nucleotide acid substitutions which are situated in the first domain (exon II) of alpha and beta genes. Specific sequences of these domains can be obtained by amplification of genomic DNA using the polymerase chain...
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