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Characterization of a Recurrent Germ Line Mutation of the <i>E-Cadherin</i> Gene: Implications for Genetic Testing and Clinical Management

1 Aug 2005

Abstract excerpt

PURPOSE: To identify germ line CDH1 mutations in hereditary diffuse gastric cancer (HDGC) families and develop guidelines for management of at risk individuals. EXPERIMENTAL DESIGN: We ascertained 31 HDGC previously unreported families, including 10 isolated early-onset diffuse gastric cancer (DGC) cases. Screening for CDH1 germ line mutations was done by denaturing high-performance liquid chromatography and...

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Identifiers

PMID: 16061854
DOI: 10.1158/1078-0432.ccr-05-0247

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