Article
Carrier detection and prenatal diagnosis in 98 families of haemophilia A by linkage analysis and direct detection of mutations.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Apr 1991
Lavergne J M, Laurian Y, Dudilleux A, Larrieu M J, Bahnak B R, Meyer D
Abstract excerpt
489 individuals from 98 families with a haemophilia A member were studied with restriction fragment length polymorphisms (RFLPs) for carrier detection and prenatal diagnosis. Five intragenic polymorphisms revealed with the restriction enzymes BclI, XbaI, BglI, HindIII and AlwNI and one extragenic...
Topics
- Alleles
- Antigens
- Base Sequence
- Factor VIII
- Female
- Genetic Carrier Screening
- Genetic Linkage
- Gestational Age
- Hemophilia A
- Humans
- Molecular Sequence Data
- Mutation