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Article

Factor VIII gene mutations and RFLP analysis in hemophilia A.

Stem cells (Dayton, Ohio) - 1 May 1993

Krepelová A, Brdicka R, Vorlová Z

Abstract excerpt

Hemophilia A is an X-linked bleeding disorder caused by a quantitative or qualitative defect of coagulation factor VIII. Since factor VIII has been cloned and several intragenic and linked DNA polymorphisms discovered, DNA analysis is an accepted and commonly used method for carrier testing in hemophilia A. Both a direct method using detection of mutation and an indirect method based on linkage between the...

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Identifiers

PMID: 8100465
DOI: 10.1002/stem.5530110615

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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