Article
Factor VIII gene mutations and RFLP analysis in hemophilia A.
Stem cells (Dayton, Ohio) - 1 May 1993
Krepelová A, Brdicka R, Vorlová Z
Abstract excerpt
Hemophilia A is an X-linked bleeding disorder caused by a quantitative or qualitative defect of coagulation factor VIII. Since factor VIII has been cloned and several intragenic and linked DNA polymorphisms discovered, DNA analysis is an accepted and commonly used method for carrier testing in he...
Topics
- DNA Mutational Analysis
- Factor VIII
- Female
- Genetic Carrier Screening
- Haplotypes
- Hemophilia A
- Humans
- Mutation
- Polymorphism, Restriction Fragment Length