Article
Evaluation of DNA-based diagnosis for haemophilia A.
Scandinavian journal of clinical and laboratory investigation - 1 Nov 1991
Wadelius C, Blombäck M, Goonewardena P, Anvret M, Lindstedt M, Gustavson K H, Pettersson U
Abstract excerpt
Haemophilia A is an X-linked disorder affecting 1.7/10,000 males. Carrier detection in females and prenatal diagnosis of male foetuses is greatly improved by DNA-based diagnosis. This study describes the use of the polymerase chain reaction (PCR) and allele-specific oligonucleotides (ASO) in a clinical study comprising 190 individuals in 27 families. Prenatal diagnosis was performed in eight cases. Of three male...
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