Article
Evaluation of DNA-based diagnosis for haemophilia A.
Scandinavian journal of clinical and laboratory investigation - 1 Nov 1991
Wadelius C, Blombäck M, Goonewardena P, Anvret M, Lindstedt M, Gustavson K H, Pettersson U
Abstract excerpt
Haemophilia A is an X-linked disorder affecting 1.7/10,000 males. Carrier detection in females and prenatal diagnosis of male foetuses is greatly improved by DNA-based diagnosis. This study describes the use of the polymerase chain reaction (PCR) and allele-specific oligonucleotides (ASO) in a cl...
Topics
- Alleles
- Base Sequence
- Blood Coagulation Tests
- Blotting, Southern
- DNA
- Genetic Carrier Screening
- Hemophilia A
- Humans
- Molecular Sequence Data
- Nucleic Acid Hybridization
- Pedigree
- Polymerase Chain Reaction