Article
Carrier detection for hemophilia B: evaluation of multiple polymorphic sites.
American journal of hematology - 1 Jan 1990
Mariani G, Chistolini A, Hassan H J, Gallo E, Gu X G, Papacchini M, Di Paolantonio T, Fantoni A
Abstract excerpt
DNA analysis was performed in families with hemophilia B. Restriction fragment length polymorphisms (RFLPs) produced by endonucleases Taql, Xmnl, and Ddel were studied by two factor IX genomic probes, F9(VIII) and F9(XIII). Fifty-seven subjects from ten families were investigated; of them, 31 wer...
Topics
- DNA Probes
- Factor IX
- Genetic Carrier Screening
- Hemophilia B
- Humans
- Mutation
- Pedigree
- Phenotype
- Polymorphism, Restriction Fragment Length
- Prenatal Diagnosis