Use of Intron 1 and 22 inversions and linkage analysis in carrier detection of hemophilia A in Indians.

doi:10.1016/j.cca.2005.08.001

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Article

Use of Intron 1 and 22 inversions and linkage analysis in carrier detection of hemophilia A in Indians.

Clinica chimica acta; international journal of clinical chemistry - 1 Mar 2006

Ahmed Rafeeq, Kannan Meganathan, Biswas Arijit, Ranjan Ravi, Choudhry Ved P, Saxena Renu

Abstract excerpt

BACKGROUND: Hemophilia A is an X-linked recessively inherited bleeding disorder characterized by deficiency of procoagulant factor VIII (FVIII). METHODS: Sixty unrelated hemophilia A patients and their family members have undergone tests for carrier detection by linkage analysis using the polymorphic markers Bcl I, Xba I and Intron 13 or 22 VNTRs. In families of sporadic hemophiliacs, the carrier status of female...

Topics

Chromosome Inversion
Female
Genetic Carrier Screening
Genetic Linkage
Hemophilia A
Humans
India
Introns
Male
Mutation

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PMID: 16129422
DOI: 10.1016/j.cca.2005.08.001

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