Carrier analysis and prenatal diagnosis of haemophilia A in North India.

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Article

Carrier analysis and prenatal diagnosis of haemophilia A in North India.

International journal of molecular medicine - 1 Nov 2002

Pandey Gouri Shanker, Phadke Shubha R, Mittal Balraj

Abstract excerpt

The feasibility of DNA diagnosis for haemophilia A in North India was evaluated using intragenic polymorphic DNA markers in factor VIII gene for linkage analysis as well as direct detection of inversion mutation in intron 22 of the gene. The informativity of RFLP (HindIII, BclI and XbaI) and STR (introns 13 and 22) markers for linkage analysis in factor VIII gene was determined in 100 normal individuals. The...

Topics

Alleles
DNA
Factor VIII
Female
Gene Frequency
Genetic Carrier Screening
Hemophilia A
Humans
India
Infant, Newborn
Male
Microsatellite Repeats
Polymorphism, Restriction Fragment Length
Pregnancy
Prenatal Diagnosis

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Open in PubMed

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PMID: 12373312

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