Article
Hypervolemia of pregnancy is not maintained in mice chronically overexpressing angiotensinogen.
American journal of obstetrics and gynecology - 1 Dec 2006
Morgan Terry K, Rohrwasser Andreas, Zhao Ling, Hillas Elaine, Cheng Tong, Ward Kenneth J, Lalouel Jean-Marc
Abstract excerpt
OBJECTIVE: Women who develop pre-eclampsia show significantly less hypervolemia of pregnancy, compared with controls. We have shown that chronically elevated angiotensinogen expression increases a woman's risk of developing pre-eclampsia. Our objective was to determine whether increased angiotensinogen expression is sufficient to cause failed hypervolemia. STUDY DESIGN: To isolate the effects of elevated...
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