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Article

The role of myostatin in muscle wasting: an overview

25 Jul 2011

Abstract excerpt

Myostatin is an extracellular cytokine mostly expressed in skeletal muscles and known to play a crucial role in the negative regulation of muscle mass. Upon the binding to activin type IIB receptor, myostatin can initiate several different signalling cascades resulting in the upregulation of the atrogenes and downregulation of the important for myogenesis genes. Muscle size is regulated via a complex interplay of...

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PMID: 21966641
DOI: 10.1007/s13539-011-0035-5

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