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Article

Attenuated strains of Mycobacterium avium subspecies paratuberculosis as vaccine candidates against Johne's disease.

Vaccine - 11 Apr 2014

Settles Erik W, Kink John A, Talaat Adel

Abstract excerpt

Mycobacterium avium subspecies paratuberculosis (M. paratuberculosis) is the causative agent of Johne's disease in ruminants. Johne's disease has a severe economic impact on the dairy industry in the USA and worldwide. In an effort to combat this disease, we screened several transposon mutants that were attenuated in the murine model of paratuberculosis for the potential use as live attenuated vaccines. Using the...

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Identifiers

PMID: 24565753
DOI: 10.1016/j.vaccine.2014.02.010

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