Article
Glucocerebrosidase mutations are an important risk factor for Lewy body disorders.
Neurology - 12 Sept 2006
Goker-Alpan O, Giasson B I, Eblan M J, Nguyen J, Hurtig H I, Lee V M-Y, Trojanowski J Q, Sidransky E
Abstract excerpt
The synucleinopathies are neurodegenerative disorders defined by inclusions composed of aberrantly fibrillized alpha-synuclein, but factors contributing to this process remain largely unknown. The authors examined the glucocerebrosidase gene in 75 autopsy specimens with different synucleinopathies and identified mutations in 23% of cases of dementia with Lewy bodies, expanding on previous findings in subjects...
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