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Article

Glucocerebrosidase, a new player changing the old rules in Lewy body diseases.

Biological chemistry - 1 Jul 2013

Yang Na-Young, Lee Yu-Na, Lee He-Jin, Kim Yoon Suk, Lee Seung-Jae

Abstract excerpt

Mutations in the gene encoding glucocerebrosidase (GBA1) cause Gaucher disease (GD), a lysosomal storage disease with recessive inheritance. Glucocerebrosidase (GCase) is a lysosomal lipid hydrolase that digests glycolipid substrates, such as glucosylceramide and glucosylsphingosine. GBA1 mutations have been implicated in Lewy body diseases (LBDs), such as Parkinson's disease and dementia with Lewy bodies....

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Identifiers

PMID: 23435096
DOI: 10.1515/hsz-2012-0322

Genes

GBA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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