Glucocerebrosidase mutations confer a greater risk of dementia during Parkinson's disease course.

doi:10.1002/mds.24045

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Article

Glucocerebrosidase mutations confer a greater risk of dementia during Parkinson's disease course.

Movement disorders : official journal of the Movement Disorder Society - 1 Mar 2012

Setó-Salvia Núria, Pagonabarraga Javier, Houlden Henry, Pascual-Sedano Berta, Dols-Icardo Oriol, Tucci Arianna, Paisán-Ruiz Coro, Campolongo Antonia, Antón-Aguirre Sofía, Martín Inés, Muñoz Laia, Bufill Enric, Vilageliu Lluïsa, Grinberg Daniel, Cozar Mónica, Blesa Rafael, Lleó Alberto, Hardy John, Kulisevsky Jaime, Clarimón Jordi

Abstract excerpt

Mutations in the glucocerebrosidase gene are associated with Parkinson's disease and Lewy body dementia. However, whether these alterations have any effect on the clinical course of Parkinson's disease is not clear. The glucocerebrosidase coding region was fully sequenced in 225 Parkinson's disease patients, 17 pathologically confirmed Lewy body dementia patients, and 186 controls from Spain. Twenty-two...

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PMID: 22173904
DOI: 10.1002/mds.24045

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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