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Article

Frequency of the thiopurine S-methyltransferase alleles in the ancient genetic population isolate of Sardinia.

Journal of clinical pharmacy and therapeutics - 1 Jun 2006

Rossino R, Vincis C, Alves S, Prata M J, Macis M D, Nucaro A L, Schirru E, Congia M

Abstract excerpt

BACKGROUND: Thiopurine S-methyltransferase (TPMT) is an enzyme involved in the normal metabolic inactivation of thiopurine drugs. Patients with intermediate or no TPMT activity are at risk of toxicity after receiving standard doses of thiopurine drugs and it was shown that inter-individual differences in response to these drugs is largely determined by genetic variation at the TPMT locus. OBJECTIVE: This study...

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Source

Identifiers

PMID: 16789994
DOI: 10.1111/j.1365-2710.2006.00736.x

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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