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Article

Retinal disease in Rpe65-deficient mice: comparison to human leber congenital amaurosis due to RPE65 mutations.

Investigative ophthalmology & visual science - 1 Oct 2010

Caruso Rafael C, Aleman Tomas S, Cideciyan Artur V, Roman Alejandro J, Sumaroka Alexander, Mullins Cristina L, Boye Sanford L, Hauswirth William W, Jacobson Samuel G

Abstract excerpt

PURPOSE: To quantify the retinal disease in Rpe65-deficient mice across a wide age span and compare the results to those in humans with Leber congenital amaurosis (LCA) caused by RPE65 mutations. METHODS: Full-field electroretinograms (ERGs) were recorded from wild-type (C57BL/6; Rpe65(+/+)) and...

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Source

Identifiers

PMID: 20484585
DOI: 10.1167/iovs.10-5559

Genes

RPE65
ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20484585-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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