Article
Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice.
Science (New York, N.Y.) - 10 Jan 2003
Lucas R J, Hattar S, Takao M, Berson D M, Foster R G, Yau K-W
Abstract excerpt
In the mammalian retina, a small subset of retinal ganglion cells (RGCs) are intrinsically photosensitive, express the opsin-like protein melanopsin, and project to brain nuclei involved in non-image-forming visual functions such as pupillary light reflex and circadian photoentrainment. We report that in mice with the melanopsin gene ablated, RGCs retrograde-labeled from the suprachiasmatic nuclei were no longer...
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