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Adoptive T cell therapy promotes the emergence of genomically altered tumor escape variants

20 Sept 2011

Abstract excerpt

Adoptive T cell therapy has been proven effective against melanoma in mice and humans. However, because most responses are incomplete or transient, cures remain rare. To maximize the efficacy of this therapy, it will be essential to gain a better understanding of the processes which result in tumor relapse. We studied these processes using B16ova murine melanoma and adoptive transfer of OT-I T cells. Transfer of...

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PMID: 21935923
DOI: 10.1002/ijc.26447

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