Virus-induced immunoinflammatory lesions in the absence of viral antigen recognition.

Article

Virus-induced immunoinflammatory lesions in the absence of viral antigen recognition.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 1998

Gangappa S, Babu J S, Thomas J, Daheshia M, Rouse B T

Abstract excerpt

Herpetic stromal keratitis (HSK) is a CD4+ T cell-controlled immunopathologic lesion in the eye that results from infection with herpes simplex virus (HSV). Target Ags involved in HSK remain undefined. In this study, we determined if HSK could be induced in animals genetically incapable of genera...

Topics

Animals
Antigen Presentation
Antigens, Viral
Keratitis, Herpetic
Mice
Mice, SCID
Mice, Transgenic
Mutation
Receptors, Antigen, T-Cell
Simplexvirus
T-Lymphocytes

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