Direct thymic involvement in anterior chamber-associated immune deviation: evidence for a nondeletional mechanism of centrally induced tolerance to extrathymic antigens in adult mice.

Abstract excerpt

Recent reports have suggested that the dichotomy between central (thymic) and peripheral T cell tolerance is not absolute and that self-tolerance in perinatal animals may also involve the intrathymic generation and release to the periphery of Ag-specific immunoregulatory T cells. We have expanded this concept to include tolerance to non self Ags administered extrathymically to adult animals. In this study, we use...

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