Article
Direct thymic involvement in anterior chamber-associated immune deviation: evidence for a nondeletional mechanism of centrally induced tolerance to extrathymic antigens in adult mice.
Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 1997
Wang Y, Goldschneider I, Foss D, Wu D Y, O'Rourke J, Cone R E
Abstract excerpt
Recent reports have suggested that the dichotomy between central (thymic) and peripheral T cell tolerance is not absolute and that self-tolerance in perinatal animals may also involve the intrathymic generation and release to the periphery of Ag-specific immunoregulatory T cells. We have expanded...
Topics
- Adoptive Transfer
- Animals
- Anterior Chamber
- Antigens
- Clonal Deletion
- Epitopes
- Female
- Hypersensitivity, Delayed
- Injections
- Mice
- Mice, Inbred BALB C
- Phenotype
- Serum Albumin, Bovine
- T-Lymphocyte Subsets
- Thymectomy
- Thymus Gland
- Trinitrobenzenes