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Article

Neural stem cells from protein tyrosine phosphatase sigma knockout mice generate an altered neuronal phenotype in culture.

BMC neuroscience - 19 Jun 2006

Kirkham David L, Pacey Laura K K, Axford Michelle M, Siu Roberta, Rotin Daniela, Doering Laurie C

Abstract excerpt

BACKGROUND: The LAR family Protein Tyrosine Phosphatase sigma (PTPsigma) has been implicated in neuroendocrine and neuronal development, and shows strong expression in specific regions within the CNS, including the subventricular zone (SVZ). We established neural stem cell cultures, grown as neurospheres, from the SVZ of PTPsigma knockout mice and sibling controls to determine if PTPsigma influences the...

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Identifiers

PMID: 16784531
DOI: 10.1186/1471-2202-7-50
PMCID: PMC1570144

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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