Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Decreased nuclear Pten in neural stem cells contributes to deficits in neuronal maturation.

Molecular autism - 1 Jun 2020

Kang Shin Chung, Jaini Ritika, Hitomi Masahiro, Lee Hyunpil, Sarn Nick, Thacker Stetson, Eng Charis

Abstract excerpt

BACKGROUND: PTEN, a syndromic autism spectrum disorder (ASD) risk gene, is mutated in approximately 10% of macrocephalic ASD cases. Despite the described genetic association between PTEN and ASD and ensuing studies, we continue to have a limited understanding of how PTEN disruption drives ASD pathogenesis and maintenance. METHODS: We derived neural stem cells (NSCs) from the dentate gyrus (DG) of Ptenm3m4 mice, a...

Topics

Join the communities discussing this publication.

Autism Spectrum Disorder
Cell Nucleus
Cell Self Renewal
Neural Stem Cells
Neurogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

PTEN Phosphohydrolase

Source

Open in PubMed Open full text

Identifiers

PMID: 32487265
DOI: 10.1186/s13229-020-00337-2
PMCID: PMC7268763

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Decreased nuclear Pten in neural stem cells contributes to deficits in neuronal maturation.PMID 32487265Read ↗

Pten deletion in adult hippocampal neural stem/progenitor cells causes cellular abnormalities and alters neurogenesis.Semantic proximity Read ↗

Autism-specific PTEN p.I135L mutation and an autism genetic background combine to dysregulate cortical neurogenesisSemantic proximity Read ↗

PTEN variant and genetic backgrounds combine to modify cerebellar neuronal differentiation in autism spectrum disorder.Semantic proximity Read ↗

Germline PTEN genotype-dependent phenotypic divergence during the early neural developmental process of forebrain organoids.Semantic proximity Read ↗

Neural transcriptome of constitutional Pten dysfunction in mice and its relevance to human idiopathic autism spectrum disorder.Semantic proximity Read ↗

Germline PTEN genotype-dependent phenotypic divergence during the early neural developmental process of forebrain organoidsSemantic proximity Read ↗

Defective Neural Stem and Progenitor Cell Proliferation in Neurodevelopmental DisordersSemantic proximity Read ↗

Pten Mutations Alter Brain Growth Trajectory and Allocation of Cell Types through Elevated -Catenin SignalingSemantic proximity Read ↗

Cell-type specific developmental defects in <i>PTEN</i> -mutant cortical organoids converge on abnormal circuit activitySemantic proximity Read ↗

Pten regulates neuronal arborization and social interaction in mice.Semantic proximity Read ↗

PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype.Semantic proximity Read ↗

Cell-type specific defects in PTEN-mutant cortical organoids converge on abnormal circuit activity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.