Article
Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits.
Nature genetics - 1 Nov 2005
Mehrabian Margarete, Allayee Hooman, Stockton Jirina, Lum Pek Yee, Drake Thomas A, Castellani Lawrence W, Suh Michael, Armour Christopher, Edwards Stephen, Lamb John, Lusis Aldons J, Schadt Eric E
Abstract excerpt
Forward genetic approaches to identify genes involved in complex traits such as common human diseases have met with limited success. Fine mapping of linkage regions and validation of positional candidates are time-consuming and not always successful. Here we detail a hybrid procedure to map loci involved in complex traits that leverages the strengths of forward and reverse genetic approaches. By integrating...
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