Article
FAT10/diubiquitin-like protein-deficient mice exhibit minimal phenotypic differences.
Molecular and cellular biology - 1 Jul 2006
Canaan Allon, Yu Xiaofeng, Booth Carmen J, Lian Jin, Lazar Isaac, Gamfi Serwa L, Castille Katrina, Kohya Naohiko, Nakayama Yasuhiro, Liu Yuan-Ching, Eynon Elizabeth, Flavell Richard, Weissman Sherman M
Abstract excerpt
The FAT10 gene encodes a diubiquitin-like protein containing two tandem head-to-tail ubiquitin-like domains. There is a high degree of similarity between murine and human FAT10 sequences at both the mRNA and protein levels. In various cell lines, FAT10 expression was shown to be induced by gamma interferon or by tumor necrosis factor alpha. In addition, FAT10 expression was found to be up-regulated in some...
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