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Article

Viable mutations of mouse midnolin suppress B cell malignancies.

The Journal of experimental medicine - 3 Jun 2024

Zhong Xue, Peddada Nagesh, Moresco James J, Wang Jianhui, Jiang Yiao, Rios Jonathan J, Moresco Eva Marie Y, Choi Jin Huk, Beutler Bruce

Abstract excerpt

In a genetic screen, we identified two viable missense alleles of the essential gene Midnolin (Midn) that were associated with reductions in peripheral B cells. Causation was confirmed in mice with targeted deletion of four of six MIDN protein isoforms. MIDN was expressed predominantly in lymphocytes where it augmented proteasome activity. We showed that purified MIDN directly stimulated 26S proteasome activity...

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Identifiers

PMID: 38625151
DOI: 10.1084/jem.20232132
PMCID: PMC11022886

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