Article

Loss-of-function of <i>Fbxo10</i> , encoding a post-translational regulator of BCL2 in lymphomas, has no discernible effect on BCL2 or B lymphocyte accumulation in mice

2020-08-05

Abstract excerpt

Regulation of the anti-apoptotic BCL2 protein determines cell survival and is frequently abnormal in B cell lymphomas. An evolutionarily conserved post-translational mechanism for over-expression of BCL2 in human B cell lymphomas and the BCL2 paralogue CED-9 in Caenorhabditis elegans results from loss-of-function mutations in human FBXO10 and its C.elegans paralogue DRE-1, a BCL2/CED-9-binding subunit of the SKP...

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Literature Corpus work: 6264d53c-d290-5ae7-851f-da5ed52dafce
DOI: 10.1101/2020.08.05.237545

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Loss-of-function of <i>Fbxo10</i> , encoding a post-translational regulator of BCL2 in lymphomas, has no discernible effect on BCL2 or B lymphocyte accumulation in miceDOI 10.1101/2020.08.05.237545Read

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