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Article

Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development.

Cancer cell - 1 Apr 2005

Mijimolle Nieves, Velasco Juan, Dubus Pierre, Guerra Carmen, Weinbaum Carolyn A, Casey Patrick J, Campuzano Victoria, Barbacid Mariano

Abstract excerpt

Protein farnesyltransferase (FTase) is an enzyme responsible for posttranslational modification of proteins carrying a carboxy-terminal CaaX motif. Farnesylation allows substrates to interact with membranes and protein targets. Using gene-targeted mice, we report that FTase is essential for embryonic development, but dispensable for adult homeostasis. Six-month-old FTase-deficient mice display delayed wound...

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Identifiers

PMID: 15837621
DOI: 10.1016/j.ccr.2005.03.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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