Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutant p53 Regulates Pyruvate Dehydrogenase Kinase 1 (PDK1) to Promote Proliferation and Migration in Breast Cancer.

Cancer science - 1 Feb 2026

Ye Yan, Ou Zuli, Li Canling, Liao Qingyu, Zeng Qian, Ju Xiaoqian, Zhang Dian, Wei Yu, Zhang Xiang, Zhang Tao, Wu Kejia

Abstract excerpt

Tumor suppressor p53 is the most frequently mutated gene in cancers. Mutations in p53 not only result in the loss of its classical tumor-suppressive functions but also confer new oncogenic properties. The protein stabilization of mutant p53 (mutp53) is a prerequisite for gain-of-function manifestation. Here, we report the novel mechanism that pyruvate dehydrogenase kinase1 (PDK1) modulates both wild-type and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to Cell Movement

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Proliferation

Share to Gene Expression Regulation, Neoplastic

Share to Mice, Nude

Share to Pyruvate Dehydrogenase Acetyl-Transferring Kinase

Share to Tumor Suppressor Protein p53

Share to Xenograft Model Antitumor Assays

Source

Open in PubMed Open full text

Identifiers

PMID: 41243575
DOI: 10.1111/cas.70252
PMCID: PMC12861101

Genes

PDK1
TP53
EGR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutant p53 Regulates Pyruvate Dehydrogenase Kinase 1 (PDK1) to Promote Proliferation and Migration in Breast Cancer.PMID 41243575Read ↗

Mutant p53 achieved Gain-of-Function by promoting tumor growth and immune escape through PHLPP2/AKT/PD-L1 pathwaySemantic proximity Read ↗

Death-associated protein kinase 1 promotes growth of p53-mutant cancers.Semantic proximity Read ↗

PDP1 promotes KRAS mutant colorectal cancer progression by serving as a scaffold for BRAF and MEK1.Semantic proximity Read ↗

Mutant p53 and mTOR/PKM2 regulation in cancer cells.Semantic proximity Read ↗

A novel mutant p53 binding partner BAG5 stabilizes mutant p53 and promotes mutant p53 GOFs in tumorigenesisSemantic proximity Read ↗

Pyruvate dehydrogenase inactivation causes glycolytic phenotype in BAP1 mutant uveal melanoma.Semantic proximity Read ↗

dapk1, encoding an activator of a p19ARF-p53-mediated apoptotic checkpoint, is a transcription target of p53.Semantic proximity Read ↗

Lipogenic enzyme FASN promotes mutant p53 accumulation and gain-of-function through palmitoylationSemantic proximity Read ↗

BAG2 promotes tumorigenesis through enhancing mutant p53 protein levels and functionSemantic proximity Read ↗

Critical Roles of DMP1 in Human Epidermal Growth Factor Receptor 2/neu-Arf-p53 Signaling and Breast Cancer DevelopmentSemantic proximity Read ↗

Crosstalk between tumor suppressors p53 and PKCδ: Execution of the intrinsic apoptotic pathways.Semantic proximity Read ↗

Cyclin B1/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.