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Article

Effect of interferon alpha on MHC class II gene expression in ex vivo human islet tissue.

Biochimica et biophysica acta - 1 Jun 2006

Harris Paul E, Malanga Donatella, Liu Zhuoro, Hardy Mark A, Souza Fabiola, Del Pozzo Giovanna, Winchester Robert J, Maffei Antonella

Abstract excerpt

Type 1 diabetes (T1D) is caused by autoimmune destruction of the insulin-producing beta-cells of the islets of Langerhans. One still open question is where naive islet-reactive T cells encounter antigens and become stimulated. In this report we have re-examined the expression of MHC class II (MHCII) genes in human islets to further explore the possibility that non-professional antigen presenting cells (APCs)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16782520
DOI: 10.1016/j.bbadis.2006.05.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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