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Article

Estrogen receptor alpha genotype confers interindividual variability of response to estrogen and testosterone in mesenchymal-stem-cell-derived osteoblasts.

Bone - 1 Nov 2006

Leskelä Hannu-Ville, Olkku Anu, Lehtonen Siri, Mahonen Anitta, Koivunen Jussi, Turpeinen Miia, Uusitalo Jouko, Pelkonen Olavi, Kangas Lauri, Selander Katri, Lehenkari Petri

Abstract excerpt

Hormone replacement therapy is effectively used to prevent postmenopausal bone loss. Variation in response to the therapy is, however, frequently seen. In addition, the direct effects of sex steroids on isolated human bone marrow stromal cells have been reported to vary depending on the donor, but the biological mechanisms are not understood. The aim of this study was to investigate the effects of...

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PMID: 16782420
DOI: 10.1016/j.bone.2006.05.003

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MSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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